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Myeloma B007

Last amended 
4 April 2016

In this section

Current RMA Instruments:

Consolidated RH SOP69 of 2012 as amended by 72 of 2014 and 39 of 2016
Consolidated BOP SOP70 of 2012 as amended by 73 of 2014
Changes from previous Instruments:

SOP Bulletin 188

ICD Coding:
  • ICD-9-CM Codes: 203.0-203.1,238.6
  • ICD-10-AM Codes: C90
Brief description

Myeloma is a cancer of plasma cells arising in the bone marrow.  Plasma cells are a type of white blood cell.

Confirming the diagnosis

Diagnosis is complex and required specialist opinion based on a range of tests including bone marrow biopsy and serum electrophoresis and immunofixation.

The relevant medical specialist is a haematologist or haematologist oncologist.

Additional diagnoses covered by SOP
  • Multiple myeloma
  • Multiple myelomatosis
  • Plasma cell leukaemia
  • Solitary myeloma
  • Solitary plasmacytoma (of bone or extramedullary site)
Conditions not covered by SOP
  • Acute myeloid leukaemia*
  • Chronic myeloid leukaemia*
  • Monoclonal gammopathy of undetermined significance#
  • Non-Hodgkin's lymphoma*

* another SOP applies

# non-SOP condition

Clinical onset

The clinical presentation is variable.  The condition may be asymptomatic and uncovered by routine blood testing or X-rays.  Bone pain is a common presenting symptom.  Clinical onset is likely to be when test results first indicate abnormalities that are subsequently confirmed to be due to myeloma, are present.  It may be possible to back date onset to an earlier time based on the presenting symptoms.

Clinical worsening

The only SOP worsening factor is for inability to obtain appropriate clinical management.  Treament may be initially effective and may prolong survival.  The usual course of myeloma is of relapse following treatment.