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Malignant Neoplasm of the Cervix B021

Last amended 
16 November 2020
Current RMA Instruments
Reasonable Hypothesis SOP
80 of 2020
Balance of Probabilities SOP
81 of 2020
Changes from previous Instruments

SOP Bulletin 217

ICD Coding
  • ICD-9-CM Codes: 180, 233.1, 622.1
  • ICD-10-AM Codes: C53, D06, N87.2
Brief description

This is a primary cancer of the uterine cervix (the neck of the uterus/womb). The RMA SOP also covers advanced precancerous lesions, known as cervical intraepithelial neoplasia (CIN) grade III (also referred to as carcinoma-in-situ and severe cervical dysplasia).

Confirming the diagnosis

This diagnosis is based on histological evaluation of a cervical biopsy.

The relevant medical specialist is a gynaecologist or gynaecological oncologist.

Additional diagnoses covered by SOP
  • Adenocarcinoma of the cervix
  • Adenosquamous carcinoma of the cervix
  • Carcinoma in situ of the cervix
  • Cervical intraepithelial neoplasia grade 3 (CIN III)
  • Severe cervical dysplasia
  • Squamous cell carcinoma of the cervix
Conditions excluded from SOP
  • Adenosarcoma of the cervix#
  • Carcinosarcoma of the cervix#
  • Cervical intraepithelial neoplasm grade 1 (CIN I)#
  • Cervical intraepithelial neoplasm grade 2 (CIN II)# 
  • Malignant melanoma of the cervix#
  • Mild cervical dysplasia# 
  • Moderate cervical dysplasia#
  • Squamous intraepithelial lesion#
  • Melanoma in situ of the cervix#
  • Soft tissue sarcoma of the cervix*
  • Non-Hodgkin lymphoma of the cervix*
  • Hodgkin’s lymphoma of the cervix*

* another SOP applies

# non-SOP condition

Clinical onset

The condition is usually asymptomatic and is detected by cervical screening or otherwise on pelvic examination.  Symptomatic presentations may include vaginal bleeding or discharge.

Clinical worsening

The only SOP worsening factor is for inability to obtain appropriate clinical management.  The appropriate treatment varies with the stage and extent of disease.  The course of the condition is highly variable, with early stage disease having a favourable prognosis.