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Mesangial IgA Glomerulonephritis K017
Current RMA Instruments
|Reasonable Hypothesis SOP||52 of 2012|
|Balance of Probabilities SOP||53 of 2012|
Changes from previous Instruments
- ICD-9-CM Codes: 583.9
- ICD-10-AM Codes: N05.9
This is an autoimmune kidney disorder. The mesangium is a layer of tissue/cells in the glomeruli in the kidney. A glomerulus is part of a filtration unit in the kidney, called a nephron, which is integral to the production of urine and which is the structural and functional unit of the kidney. Glomerulonephritis is inflammation of the glomeruli/nephrons. IgA is an immunoglobulin which gets deposited in the mesangium in this disease.
Confirming the diagnosis
This diagnosis can only be made following a renal biopsy, with a pathologist providing a histological report (including immunofluorescence or immunoperoxidase studies).
The relevant medical specialist is a nephrologist.
Additional diagnoses covered by SOP
- Berger’s disease
- IgA nephropathy (with haematuria or proteinuria)
Conditions excluded from SOP
- Nephritic syndrome – Too non-specific but this clinical picture may arise from the IgA mesangial glomerulonephritis.
- Nephrotic syndrome – Too non-specific but this clinical picture may arise from the IgA mesangial glomerulonephritis
- Glomerulonephritis – too non-specific
- Henoch-Schonlein purpura#
# nonSOP condition
Onset can be at any age, but is most common in the second or third decade of life. The condition mostly presents with haematuria (blood in the urine), either visible, or detected on urine testing. Some patients present with nephrotic syndrome (swelling (oedema), elevated blood pressure and impaired kidney function).
Around half of patients have a benign and stable course with persistent low grade haematuria or proteinuria. The remainder typically progress slowly to end-stage renal failure over several decades. Markers of worsening disease include declining renal function, increasing urinary protein excretion and worsening hypertension.