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Acute lymphoblastic leukaemia B014

Last amended 
4 April 2016
Current RMA Instruments:
Consolidated RH SOP
75 of 2012 as amended by 37 of 2016
Balance of Probabilities SOP
76 of 2012
Changes from previous Instruments:

SOP Bulletin 188

ICD Coding:
  • ICD-9-CM Codes: 204.0
  • ICD-10-AM Codes: C91.0
Brief description

This is a cancer of immature white blood cells (lymphoblasts).

Confirming the diagnosis

A bone marrow biopsy is the definitive test for diagnosis.

The relevant medical specialist is a haematologist.

Diagnoses covered by SOP
  • acute lymphoid leukaemia
  • acute lymphocytic leukaemia
Conditions excluded from SOP
  • acute myeloid leukaemia*
  • adult T-cell leukaemia/lymphoma* (non-Hodgkin's lymphoma SOP)
  • Burkitt’s lymphoma/leukaemia* (non-Hodgkin's lymphoma SOP)
  • chronic lymphoid leukaemia*
  • chronic myeloid leukaemia*
  • non-Hodgkin’s lymphoma*

* another SOP applies

Clinical onset

Clinical onset will be when the diagnosis was confirmed, or shortly before that time if characteristic symptoms were present, such as easy bruising/bleeding, recurrent infections or symptoms from anaemia.

Clinical worsening

The only worsening factor is for inability to obtain appropriate clinical management.  The prognosis in adults is generally poor.  Worsening beyond the normal progression of the disease will be difficult to establish and will require speciailist opinion.