Acute Lymphoblastic Leukaemia / Lymphoblastic Lymphoma B014
Current RMA Instruments
| Reasonable Hypothesis SOP | 33 of 2021 |
| Balance of Probabilities SOP | 34 of 2021 |
Changes from previous Instruments
ICD Coding
- ICD-9-CM Codes: 204.0
- ICD-10-AM Codes: C91.0
Brief description
This is a cancer of immature white blood cells (lymphoblasts). There are two overlapping clinical presentations of the same disease - leukaemia, when bone marrow blast cells predominate, and lymphoma, when a mass lesion in the mediastinum or elsewhere is the predominant feature.
Confirming the diagnosis
Diagnosis is usually suspected based on a finding of swollen lymph nodes or a blood test showing abnormal white cells. A bone marrow biopsy is required to confirm the diagnosis and differentiate the condition from other diseases.
The relevant medical specialist is a haematologist.
Diagnoses covered by SOP
- acute lymphoid leukaemia
- acute lymphocytic leukaemia
- B-lymphoblastic leukemia/lymphoma (B-ALL/LBL)
- T-lymphoblastic leukemia/lymphoma (T-ALL/LBL)
- lymphoblastic lymphoma
Conditions excluded from SOP
- acute myeloid leukaemia*
- acute undifferentiated leukaemia#
- adult T-cell leukaemia/lymphoma* (non-Hodgkin lymphoma SOP)
- Burkitt’s lymphoma/leukaemia* (non-Hodgkin lymphoma SOP)
- chronic lymphoid leukaemia*
- chronic myeloid leukaemia*
- indolent T-lymphoblastic proliferation#
- non-Hodgkin lymphoma*
* another SOP applies
# non-SOP condition
Clinical onset
Clinical onset will be when the diagnosis was confirmed, or shortly before that time if characteristic symptoms were present, such as easy bruising/bleeding, recurrent infections or symptoms from anaemia. 75% of cases occur in children under 6, but there is a second peak in adults > 60 years old.
Clinical worsening
The only worsening factor is for inability to obtain appropriate clinical management. The prognosis in adults is generally poor. Worsening beyond the normal progression of the disease will be difficult to establish and will require specialist opinion.
Source URL: https://clik.dva.gov.au/ccps-medical-research-library/sops-grouped-icd-body-system/b/acute-lymphoblastic-leukaemia-b014-c910-c915
Rulebase for acute lymphoid leukaemia
<h5>Current RMA Instruments</h5><table border="1" cellspacing="1" cellpadding="1"><tbody><tr><td><address><a href="http://www.rma.gov.au/assets/SOP/2021/eae501d9e8/033.pdf" target="_blank">Reasonable Hypothesis SOP</a></address></td><td>33 of 2021</td></tr><tr><td><address><a href="http://www.rma.gov.au/assets/SOP/2021/705c092af2/034.pdf" target="_blank">Balance of Probabilities SOP</a></address></td><td>34 of 2021</td></tr></tbody></table><h5>Changes from previous Instruments</h5><p><drupal-media data-entity-type="media" data-entity-uuid="65e99c24-8c40-472e-88ae-cb011637fc39" data-view-mode="wysiwyg"></drupal-media></p><h5>ICD Coding</h5><ul><li>ICD-9-CM Codes: 204.0</li><li>ICD-10-AM Codes: C91.0</li></ul><h5>Brief description</h5><p>This is a cancer of immature white blood cells (lymphoblasts). There are two overlapping clinical presentations of the same disease - leukaemia, when bone marrow blast cells predominate, and lymphoma, when a mass lesion in the mediastinum or elsewhere is the predominant feature.</p><h5>Confirming the diagnosis</h5><p>Diagnosis is usually suspected based on a finding of swollen lymph nodes or a blood test showing abnormal white cells. A bone marrow biopsy is required to confirm the diagnosis and differentiate the condition from other diseases.</p><p>The relevant medical specialist is a haematologist.</p><h5>Diagnoses covered by SOP</h5><ul><li>acute lymphoid leukaemia</li><li>acute lymphocytic leukaemia</li><li>B-lymphoblastic leukemia/lymphoma (B-ALL/LBL)</li><li>T-lymphoblastic leukemia/lymphoma (T-ALL/LBL)</li><li>lymphoblastic lymphoma</li></ul><h5><b>Conditions excluded from SOP</b></h5><ul><li>acute myeloid leukaemia*</li><li>acute undifferentiated leukaemia<span><sup>#</sup></span></li><li>adult T-cell leukaemia/lymphoma* (non-Hodgkin lymphoma SOP)</li><li>Burkitt’s lymphoma/leukaemia* (non-Hodgkin lymphoma SOP)</li><li>chronic lymphoid leukaemia*</li><li>chronic myeloid leukaemia*</li><li>indolent T-lymphoblastic proliferation<span><sup>#</sup></span></li><li>non-Hodgkin lymphoma*</li></ul><p>* another SOP applies</p><p><span><sup>#</sup></span> non-SOP condition</p><h5><b>Clinical onset</b></h5><p>Clinical onset will be when the diagnosis was confirmed, or shortly before that time if characteristic symptoms were present, such as easy bruising/bleeding, recurrent infections or symptoms from anaemia. 75% of cases occur in children under 6, but there is a second peak in adults > 60 years old.</p><h5>Clinical worsening</h5><p>The only worsening factor is for inability to obtain appropriate clinical management. The prognosis in adults is generally poor. Worsening beyond the normal progression of the disease will be difficult to establish and will require specialist opinion.</p>
Source URL: https://clik.dva.gov.au/ccps-medical-research-library/statements-principles/b/acute-lymphoblastic-leukaemia-b014-c910-c915/rulebase-acute-lymphoid-leukaemia
A course of therapeutic radiation
Current RMA Instruments
| Reasonable Hypothesis SOP | 33 of 2021 |
| Balance of Probabilities SOP | 34 of 2021 |
Changes from previous Instruments
ICD Coding
- ICD-9-CM Codes: 204.0
- ICD-10-AM Codes: C91.0
Brief description
This is a cancer of immature white blood cells (lymphoblasts). There are two overlapping clinical presentations of the same disease - leukaemia, when bone marrow blast cells predominate, and lymphoma, when a mass lesion in the mediastinum or elsewhere is the predominant feature.
Confirming the diagnosis
Diagnosis is usually suspected based on a finding of swollen lymph nodes or a blood test showing abnormal white cells. A bone marrow biopsy is required to confirm the diagnosis and differentiate the condition from other diseases.
The relevant medical specialist is a haematologist.
Diagnoses covered by SOP
- acute lymphoid leukaemia
- acute lymphocytic leukaemia
- B-lymphoblastic leukemia/lymphoma (B-ALL/LBL)
- T-lymphoblastic leukemia/lymphoma (T-ALL/LBL)
- lymphoblastic lymphoma
Conditions excluded from SOP
- acute myeloid leukaemia*
- acute undifferentiated leukaemia#
- adult T-cell leukaemia/lymphoma* (non-Hodgkin lymphoma SOP)
- Burkitt’s lymphoma/leukaemia* (non-Hodgkin lymphoma SOP)
- chronic lymphoid leukaemia*
- chronic myeloid leukaemia*
- indolent T-lymphoblastic proliferation#
- non-Hodgkin lymphoma*
* another SOP applies
# non-SOP condition
Clinical onset
Clinical onset will be when the diagnosis was confirmed, or shortly before that time if characteristic symptoms were present, such as easy bruising/bleeding, recurrent infections or symptoms from anaemia. 75% of cases occur in children under 6, but there is a second peak in adults > 60 years old.
Clinical worsening
The only worsening factor is for inability to obtain appropriate clinical management. The prognosis in adults is generally poor. Worsening beyond the normal progression of the disease will be difficult to establish and will require specialist opinion.
Source URL: https://clik.dva.gov.au/ccps-medical-research-library/statements-principles/b/acute-lymphoblastic-leukaemia-b014-c910-c915/rulebase-acute-lymphoid-leukaemia/course-therapeutic-radiation
Atomic radiation
Current RMA Instruments
| Reasonable Hypothesis SOP | 33 of 2021 |
| Balance of Probabilities SOP | 34 of 2021 |
Changes from previous Instruments
ICD Coding
- ICD-9-CM Codes: 204.0
- ICD-10-AM Codes: C91.0
Brief description
This is a cancer of immature white blood cells (lymphoblasts). There are two overlapping clinical presentations of the same disease - leukaemia, when bone marrow blast cells predominate, and lymphoma, when a mass lesion in the mediastinum or elsewhere is the predominant feature.
Confirming the diagnosis
Diagnosis is usually suspected based on a finding of swollen lymph nodes or a blood test showing abnormal white cells. A bone marrow biopsy is required to confirm the diagnosis and differentiate the condition from other diseases.
The relevant medical specialist is a haematologist.
Diagnoses covered by SOP
- acute lymphoid leukaemia
- acute lymphocytic leukaemia
- B-lymphoblastic leukemia/lymphoma (B-ALL/LBL)
- T-lymphoblastic leukemia/lymphoma (T-ALL/LBL)
- lymphoblastic lymphoma
Conditions excluded from SOP
- acute myeloid leukaemia*
- acute undifferentiated leukaemia#
- adult T-cell leukaemia/lymphoma* (non-Hodgkin lymphoma SOP)
- Burkitt’s lymphoma/leukaemia* (non-Hodgkin lymphoma SOP)
- chronic lymphoid leukaemia*
- chronic myeloid leukaemia*
- indolent T-lymphoblastic proliferation#
- non-Hodgkin lymphoma*
* another SOP applies
# non-SOP condition
Clinical onset
Clinical onset will be when the diagnosis was confirmed, or shortly before that time if characteristic symptoms were present, such as easy bruising/bleeding, recurrent infections or symptoms from anaemia. 75% of cases occur in children under 6, but there is a second peak in adults > 60 years old.
Clinical worsening
The only worsening factor is for inability to obtain appropriate clinical management. The prognosis in adults is generally poor. Worsening beyond the normal progression of the disease will be difficult to establish and will require specialist opinion.
Source URL: https://clik.dva.gov.au/ccps-medical-research-library/statements-principles/b/acute-lymphoblastic-leukaemia-b014-c910-c915/rulebase-acute-lymphoid-leukaemia/atomic-radiation
HTLV-1 infection
Current RMA Instruments
| Reasonable Hypothesis SOP | 33 of 2021 |
| Balance of Probabilities SOP | 34 of 2021 |
Changes from previous Instruments
ICD Coding
- ICD-9-CM Codes: 204.0
- ICD-10-AM Codes: C91.0
Brief description
This is a cancer of immature white blood cells (lymphoblasts). There are two overlapping clinical presentations of the same disease - leukaemia, when bone marrow blast cells predominate, and lymphoma, when a mass lesion in the mediastinum or elsewhere is the predominant feature.
Confirming the diagnosis
Diagnosis is usually suspected based on a finding of swollen lymph nodes or a blood test showing abnormal white cells. A bone marrow biopsy is required to confirm the diagnosis and differentiate the condition from other diseases.
The relevant medical specialist is a haematologist.
Diagnoses covered by SOP
- acute lymphoid leukaemia
- acute lymphocytic leukaemia
- B-lymphoblastic leukemia/lymphoma (B-ALL/LBL)
- T-lymphoblastic leukemia/lymphoma (T-ALL/LBL)
- lymphoblastic lymphoma
Conditions excluded from SOP
- acute myeloid leukaemia*
- acute undifferentiated leukaemia#
- adult T-cell leukaemia/lymphoma* (non-Hodgkin lymphoma SOP)
- Burkitt’s lymphoma/leukaemia* (non-Hodgkin lymphoma SOP)
- chronic lymphoid leukaemia*
- chronic myeloid leukaemia*
- indolent T-lymphoblastic proliferation#
- non-Hodgkin lymphoma*
* another SOP applies
# non-SOP condition
Clinical onset
Clinical onset will be when the diagnosis was confirmed, or shortly before that time if characteristic symptoms were present, such as easy bruising/bleeding, recurrent infections or symptoms from anaemia. 75% of cases occur in children under 6, but there is a second peak in adults > 60 years old.
Clinical worsening
The only worsening factor is for inability to obtain appropriate clinical management. The prognosis in adults is generally poor. Worsening beyond the normal progression of the disease will be difficult to establish and will require specialist opinion.
Source URL: https://clik.dva.gov.au/ccps-medical-research-library/statements-principles/b/acute-lymphoblastic-leukaemia-b014-c910-c915/rulebase-acute-lymphoid-leukaemia/htlv-1-infection
Inability to obtain appropriate clinical management for acute lymphoid leukaemia
Current RMA Instruments
| Reasonable Hypothesis SOP | 33 of 2021 |
| Balance of Probabilities SOP | 34 of 2021 |
Changes from previous Instruments
ICD Coding
- ICD-9-CM Codes: 204.0
- ICD-10-AM Codes: C91.0
Brief description
This is a cancer of immature white blood cells (lymphoblasts). There are two overlapping clinical presentations of the same disease - leukaemia, when bone marrow blast cells predominate, and lymphoma, when a mass lesion in the mediastinum or elsewhere is the predominant feature.
Confirming the diagnosis
Diagnosis is usually suspected based on a finding of swollen lymph nodes or a blood test showing abnormal white cells. A bone marrow biopsy is required to confirm the diagnosis and differentiate the condition from other diseases.
The relevant medical specialist is a haematologist.
Diagnoses covered by SOP
- acute lymphoid leukaemia
- acute lymphocytic leukaemia
- B-lymphoblastic leukemia/lymphoma (B-ALL/LBL)
- T-lymphoblastic leukemia/lymphoma (T-ALL/LBL)
- lymphoblastic lymphoma
Conditions excluded from SOP
- acute myeloid leukaemia*
- acute undifferentiated leukaemia#
- adult T-cell leukaemia/lymphoma* (non-Hodgkin lymphoma SOP)
- Burkitt’s lymphoma/leukaemia* (non-Hodgkin lymphoma SOP)
- chronic lymphoid leukaemia*
- chronic myeloid leukaemia*
- indolent T-lymphoblastic proliferation#
- non-Hodgkin lymphoma*
* another SOP applies
# non-SOP condition
Clinical onset
Clinical onset will be when the diagnosis was confirmed, or shortly before that time if characteristic symptoms were present, such as easy bruising/bleeding, recurrent infections or symptoms from anaemia. 75% of cases occur in children under 6, but there is a second peak in adults > 60 years old.
Clinical worsening
The only worsening factor is for inability to obtain appropriate clinical management. The prognosis in adults is generally poor. Worsening beyond the normal progression of the disease will be difficult to establish and will require specialist opinion.
Source URL: https://clik.dva.gov.au/ccps-medical-research-library/statements-principles/b/acute-lymphoblastic-leukaemia-b014-c910-c915/rulebase-acute-lymphoid-leukaemia/inability-obtain-appropriate-clinical-management-acute-lymphoid-leukaemia
Infection with the Epstein-Barr virus
Current RMA Instruments
| Reasonable Hypothesis SOP | 33 of 2021 |
| Balance of Probabilities SOP | 34 of 2021 |
Changes from previous Instruments
ICD Coding
- ICD-9-CM Codes: 204.0
- ICD-10-AM Codes: C91.0
Brief description
This is a cancer of immature white blood cells (lymphoblasts). There are two overlapping clinical presentations of the same disease - leukaemia, when bone marrow blast cells predominate, and lymphoma, when a mass lesion in the mediastinum or elsewhere is the predominant feature.
Confirming the diagnosis
Diagnosis is usually suspected based on a finding of swollen lymph nodes or a blood test showing abnormal white cells. A bone marrow biopsy is required to confirm the diagnosis and differentiate the condition from other diseases.
The relevant medical specialist is a haematologist.
Diagnoses covered by SOP
- acute lymphoid leukaemia
- acute lymphocytic leukaemia
- B-lymphoblastic leukemia/lymphoma (B-ALL/LBL)
- T-lymphoblastic leukemia/lymphoma (T-ALL/LBL)
- lymphoblastic lymphoma
Conditions excluded from SOP
- acute myeloid leukaemia*
- acute undifferentiated leukaemia#
- adult T-cell leukaemia/lymphoma* (non-Hodgkin lymphoma SOP)
- Burkitt’s lymphoma/leukaemia* (non-Hodgkin lymphoma SOP)
- chronic lymphoid leukaemia*
- chronic myeloid leukaemia*
- indolent T-lymphoblastic proliferation#
- non-Hodgkin lymphoma*
* another SOP applies
# non-SOP condition
Clinical onset
Clinical onset will be when the diagnosis was confirmed, or shortly before that time if characteristic symptoms were present, such as easy bruising/bleeding, recurrent infections or symptoms from anaemia. 75% of cases occur in children under 6, but there is a second peak in adults > 60 years old.
Clinical worsening
The only worsening factor is for inability to obtain appropriate clinical management. The prognosis in adults is generally poor. Worsening beyond the normal progression of the disease will be difficult to establish and will require specialist opinion.
Source URL: https://clik.dva.gov.au/ccps-medical-research-library/statements-principles/b/acute-lymphoblastic-leukaemia-b014-c910-c915/rulebase-acute-lymphoid-leukaemia/infection-epstein-barr-virus