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Toxic Retinopathy F085

Last amended 
5 March 2018
Current RMA Instruments
Reasonable Hypothesis SOP19 of 2018
Balance of Probabilities SOP20 of 2018
Changes from previous Instruments

SOP Bulletin 201

ICD Coding
  • ICD-9-CM Codes: 362.55
  • ICD-10-AM Codes: H35.35
Brief description

This SOP covers damage to the retina, resulting in non-reversible loss of vision, due to the effects of a drug or other chemical agent.

Confirming the diagnosis

This diagnosis is technically difficult and is a diagnosis of exclusion. 

The relevant medical specialist is an ophthalmologist.

Additional diagnoses covered by SOP
  • chemically-induced cystoid macular oedema
  • crystalline retinopathy
  • Macular component of a toxic retinopathy
  • toxic maculopathy
Conditions excluded from SOP
  • Age-related macular degeneration*
  • Cellophane maculopathy#
  • Diabetic retinopathy# (propagates to diabetes mellitus SOP)
  • Retinal detachment#
  • Retinal vascular occlusive disease*
  • Retinitis pigmentosa#
  • Toxic amblyopia#
  • Toxic optic neuropathy#
  • Zonal occult outer retinopathy#

* another SOP applies

# non-SOP condition

Clinical onset

Onset may be insidious, particularly if quinoline drugs are involved, or for other agents, may be soon after exposure commenced.  Changes in vision may be noticed or the condition first found on ophthalmological examination. 

Clinical worsening

The only worsening factor is for inability to obtain appropriate clinical management.  Appropriate management may include ceasing a drug that has caused toxic retinopathy.