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Methotrexate

Document

Cirrhosis of the liver - Methotrexate Factor

Last reviewed for CCPS 12 March 2008.

Investigative Documents

Medical Report - Methotrexate - Cirrhosis of the Liver [MR9405]

Preliminary questions [20507]

22395

there is some evidence that treatment with methotrexate may be a factor in the development or worsening of the condition under consideration.

20568 the veteran has been treated with methotrexate as specified in the reasonable hypothesis Statement of Principles for cirrhosis of the liver at some time.

20580

the treatment with methotrexate as specified in the reasonable hypothesis Statement of Principles for cirrhosis of the liver was materially contributed to by treatment of an illness or injury which is identifiable.

20569the veteran has established the causal connection between the treatment with methotrexate and VEA service for cirrhosis of the liver.

20570the veteran has established the causal connection between the treatment with methotrexate and VEA service for the clinical onset of cirrhosis of the liver.

20573the veteran has established the causal connection between the treatment with methotrexate and eligible service for the clinical onset of cirrhosis of the liver.

or

20572the veteran has established the causal connection between the treatment with methotrexate and operational service for the clinical onset of cirrhosis of the liver.

or

7334

the clinical onset of the condition under consideration occurred after the end of the veteran's last period of VEA service.

7335

the condition under consideration permanently worsened.

20571the veteran has established the causal connection between the treatment with methotrexate and VEA service for the clinical worsening of cirrhosis of the liver.

20575the veteran has established the causal connection between the treatment with methotrexate and eligible service for the clinical worsening of cirrhosis of the liver.

or

20574the veteran has established the causal connection between the treatment with methotrexate and operational service for the clinical worsening of cirrhosis of the liver.

Clinical onset and operational service [20572]

20576

the identified illness or injury made a material contribution to the veteran being treated with methotrexate as specified in the reasonable hypothesis Statement of Principles before the clinical onset of cirrhosis of the liver.

20581the identified illness or injury which made a material contribution to the veteran being treated with methotrexate as specified in the reasonable hypothesis Statement of Principles for cirrhosis of the liver is causally related to operational service.

Clinical onset and eligible service [20573]

25657

the identified illness or injury made a material contribution to the veteran being treated with methotrexate as specified in the balance of probabilities Statement of Principles for cirrhosis of the liver.

20577

the identified illness or injury made a material contribution to the veteran being treated with methotrexate as specified in the balance of probabilities Statement of Principles before the clinical onset of cirrhosis of the liver.

20582the identified illness or injury which made a material contribution to the veteran being treated with methotrexate as specified in the balance of probabilities Statement of Principles for cirrhosis of the liver is causally related to eligible service.

Clinical worsening and operational service [20574]

20578

the identified illness or injury made a material contribution to the veteran being treated with methotrexate as specified in the reasonable hypothesis Statement of Principles after the clinical onset of cirrhosis of the liver and before its clinical worsening.

20581the identified illness or injury which made a material contribution to the veteran being treated with methotrexate as specified in the reasonable hypothesis Statement of Principles for cirrhosis of the liver is causally related to operational service.

22163

the clinical onset of cirrhosis of the liver occurred prior to that part of operational service to which the identified illness or injury which made a material contribution to the veteran being treated with methotrexate as specified in the reasonable hypothesis Statement of Principles for cirrhosis of the liver is causally related.

Clinical worsening and eligible service [20575]

25657

the identified illness or injury made a material contribution to the veteran being treated with methotrexate as specified in the balance of probabilities Statement of Principles for cirrhosis of the liver.

20579

the identified illness or injury made a material contribution to the veteran being treated with methotrexate as specified in the balance of probabilities Statement of Principles after the clinical onset of cirrhosis of the liver and before its clinical worsening.

20582the identified illness or injury which made a material contribution to the veteran being treated with methotrexate as specified in the balance of probabilities Statement of Principles for cirrhosis of the liver is causally related to eligible service.

22162

the clinical onset of cirrhosis of the liver occurred prior to that part of eligible service to which the identified illness or injury which made a material contribution to the veteran being treated with methotrexate as specified in the balance of probabilities Statement of Principles for cirrhosis of the liver is causally related.