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Chronic Myeloid Leukaemia B016

Last amended 
24 October 2019
Current RMA Instruments
Reasonable Hypothesis SOP
47 of 2014 as amended
Balance of Probabilities SOP48 of 2014 as amended
Changes from previous Instruments

SOP Bulletin 174

ICD Coding
  • ICD-9-CM Codes: 205.1, 206.1, 208.1
  • ICD-10-AM Codes: C92.1
Brief description

This is a malignant neoplasm of white blood cells, involving increased and unregulated growth of the myeloid line of white blood cells in the bone marrow.

Confirming the diagnosis 

Confirmation of the diagnosis is typically based on findings from bone marrow aspiration and biopsy together with genetic testing. 

The relevant medical specialists are a haematologist and a pathologist.

Additional diagnoses covered by SOP
  • Chronic myelogenous leukaemia
  • Chronic granulocytic leukaemia
  • Chronic myeloblastic leukaemia
  • Chronic myelocytic leukaemia
Conditions excluded from SOP
  • Acute myeloid leukaemia*
  • Chronic lymphocytic leukaemia*
  • Chronic lymphoid leukaemia*
  • Chronic myelomonocytic leukaemia# 
  • Myelodysplastic disorder*

* another SOP applies

non-SOP condition

Clinical onset

The condition may be asymptomatic and first suspected following a blood test.  Symptomatic presentations may include, fatigue, weight loss, bleeding episodes, excessive sweating and abdominal fullness.  An enlarged spleen may be found on examination.  Average age of onset is around 60 years old.

Clinical worsening

The only SOP worsening factor is for inability to obtain appropriate clinical management.  The condition is potentially curable with a hematopoietic cell transplant.  The condition can now also be controlled long term (without cure) using tyrosine kinase inhibitors.