Reasonable Hypothesis SOP [1] | 21 of 2024 as amended |
Balance of Probabilities SOP [2] | 22 of 2024 as amended |
Acute myeloid leukaemia (AML) is a type of cancer that affects the blood and bone marrow. It involves rapid growth of abnormal white blood cells that accumulate in the bone marrow, the blood and other tissues. There is disruption of production of normal blood cells. 'Myeloid' refers to the type of cell the leukaemia starts from.
Diagnosis usually requires bone marrow biopsy.
The relevant medical specialist is haematologist or a haematologist oncologist.
* another SOP applies - the SOP has the same name unless otherwise specified
# non-SOP condition
Clinical onset will most likely be at the time of diagnosis. Early symtpoms are generally vague and non-specific. A slight back-dating of onset may be possible if symptoms of anaemia or of easy bruising/bleeding were present.
AML is a rapidly progressing disease and is typically fatal within weeks or months if left untreated. The only SoP worsening factor is for inability to obtain appropriate clincial management. Treatment may be curative (particularly in younger subjects) and will generally prolong survival. Any delay in treatment is likely to be detrimental.
Undergoing treatment with radioactive iodine or phosphorus does not include diagnostic procedures where these agents as used as tracers.
Place holder node for Rulebase for acute myeloid leukaemia
Acute myeloid leukaemia - Atomic radiation Factor
Last reviewed for CCPS 08 January 2007.
Investigative Documents
Claimant Report - Exposure to Atomic Radiation [CR9171] Preliminary questions [1404]
36765 — the veteran has established the causal connection between atomic radiation and VEA service for the clinical onset of acute myeloid leukaemia.
36766 — the veteran has established the causal connection between atomic radiation and operational service for the clinical onset of acute myeloid leukaemia.
or
36767 — the veteran has established the causal connection between atomic radiation and eligible service for the clinical onset of acute myeloid leukaemia.
Clinical onset and operational service [36766]
31995 [6] the veteran received a cumulative equivalent dose of at least 0.01 Sievert of atomic radiation to the bone marrow. the veteran received a cumulative equivalent dose of at least 0.01 Sievert of atomic radiation to the bone marrow where this dose was accumulated at least one year before the clinical onset of the condition under consideration. the veteran's operational service made a material contribution to the cumulative equivalent dose of at least 0.01 Sievert of atomic radiation to the bone marrow where this dose was accumulated at least one year before the clinical onset of the condition under consideration. the cumulative equivalent dose of at least 0.01 Sievert of atomic radiation to the bone marrow, to which operational service made a material contribution and this dose was accumulated at least one year before the clinical onset of the condition under consideration, was due to the veteran's serious default, wilful act or serious breach of discipline. Clinical onset and eligible service [36767]
Acute myeloid leukaemia - Being exposed to benzene Factor
Last reviewed for CCPS 08 January 2007.
Investigative Documents
Claimant Report - Exposure to Benzene [CR9087] Preliminary questions [22557]
22559 — the veteran has established the causal connection between being exposed to benzene and VEA service for the clinical onset of acute myeloid leukaemia.
22560 — the veteran has established the causal connection between being exposed to benzene and operational service for the clinical onset of acute myeloid leukaemia.
or
22561 — the veteran has established the causal connection between being exposed to benzene and eligible service for the clinical onset of acute myeloid leukaemia.
Clinical onset and operational service [22560]
22562 [15] the veteran was exposed to benzene on at least 300 days within a continuous two year period before the clinical onset of the condition under consideration. where the veteran was exposed to benzene on at least 300 days within a continuous two year period before the clinical onset of the condition under consideration, the first exposure occurred more than 5 years before the clinical onset of the condition under consideration. operational service made a material contribution to the veteran being exposed to benzene on at least 300 days within a continuous two year period before the clinical onset of the condition under consideration where the first exposure occurred more than 5 years before the clinical onset of the condition under consideration. Clinical onset and eligible service [22561]
Acute myeloid leukaemia - Being obese Factor
Last reviewed for CCPS 08 January 2007.
Investigative Documents
Claimant Report - Obesity [CR9230] [22] Medical Report - Obesity [MR9305] Preliminary questions [36787]
587 [24] the veteran has a history of obesity. 36786 — the veteran has established the causal connection between being obese and operational service for the clinical onset of acute myeloid leukaemia. Clinical onset and operational service [36786] or
36785 [30] the veteran was morbidly obese for a period of at least five years, within the ten years before the clinical onset of acute myeloid leukaemia.
9005 — the morbid obesity is causally related to operational service. [31]
Acute myeloid leukaemia - Chemotherapy Factor
Last reviewed for CCPS 08 January 2007.
Preliminary questions [5328]
7618 [32] there is some evidence that chemotherapy may be a factor in the development of the condition under consideration.
5329 [33] the veteran has had a course of chemotherapy at some time.
22575 [34] the veteran has had a course of chemotherapy before the clinical onset of acute myeloid leukaemia. the course of chemotherapy commenced at least six months before the clinical onset of acute myeloid leukaemia. the course of chemotherapy commenced at least six months before the clinical onset of acute myeloid leukaemia, and, where that therapy has ceased, the clinical onset occurred within twenty years of cessation. [37]
5332 — the course of chemotherapy was undertaken for an illness or injury which is identifiable. [Default true]
5333 — the veteran has established the causal connection between the course of chemotherapy and VEA service for the clinical onset of acute myeloid leukaemia.
5334 — the veteran has established the causal connection between the course of chemotherapy and operational service for the clinical onset of acute myeloid leukaemia.
or
5335 — the veteran has established the causal connection between the course of chemotherapy and eligible service for the clinical onset of acute myeloid leukaemia.
Clinical onset and operational service [5334]
5336 — the identified illness or injury for which the course of chemotherapy was undertaken is causally related to operational service. [38] [39]
Clinical onset and eligible service [5335]
5337 — the identified illness or injury for which the course of chemotherapy was undertaken is causally related to eligible service. [40] [39]
Acute myeloid leukaemia - Cigar smoking Factor
Last reviewed for CCPS 08 January 2007.
Investigative Documents
Claimant Report - Smoking [CRD905] [41] Claimant Report - Smoking [CRV905] Preliminary questions [22138]
4915 [43] the veteran has ever smoked cigars. 22136 — the veteran has established the causal connection between the cigar smoking and VEA service for the clinical onset of acute myeloid leukaemia. 22140 — the veteran has established the causal connection between the cigar smoking and operational service for the clinical onset of acute myeloid leukaemia. or 22141 — the veteran has established the causal connection between the cigar smoking and eligible service for the clinical onset of acute myeloid leukaemia. Clinical onset and operational service [22140] 4921 — the veteran has some period or periods of cigar smoking that are causally related to operational service. [45] Clinical onset and eligible service [22141]
4922 — the veteran has some period or periods of cigar smoking that are causally related to eligible service. [48]
Acute myeloid leukaemia - Cigarette smoking Factor
Last reviewed for CCPS 08 January 2007.
Investigative Documents
Claimant Report - Smoking [CRD905] [41] Claimant Report - Smoking [CRV905] Preliminary questions [883] 21792 — the veteran has established the causal connection between the cigarette smoking and VEA service for the clinical onset of acute myeloid leukaemia. 21793 — the veteran has established the causal connection between the cigarette smoking and operational service for the clinical onset of acute myeloid leukaemia. or 21794 — the veteran has established the causal connection between the cigarette smoking and eligible service for the clinical onset of acute myeloid leukaemia. Clinical onset and operational service [21793] 3116 — the veteran has some period or periods of cigarette smoking that are causally related to operational service. [51] Clinical onset and eligible service [21794]
3521 — the veteran has some period or periods of cigarette smoking that are causally related to eligible service. [53]
Acute myeloid leukaemia - Cumulative exposure to benzene Factor
Last reviewed for CCPS 08 January 2007.
Investigative Documents
Claimant Report - Exposure to Benzene [CR9087] Preliminary questions [36788]
36790 — the veteran has established the causal connection between cumulative exposure to benzene and VEA service for the clinical onset of acute myeloid leukaemia.
36791 — the veteran has established the causal connection between cumulative exposure to benzene and operational service for the clinical onset of acute myeloid leukaemia.
or
36792 — the veteran has established the causal connection between cumulative exposure to benzene and eligible service for the clinical onset of acute myeloid leukaemia.
Clinical onset and operational service [36791]
36793 [54] the veteran has received greater than 20 ppm-years of cumulative exposure to benzene before the clinical onset of the condition under consideration. where the veteran received greater than 20 ppm-years of cumulative exposure to benzene before the clinical onset of the condition under consideration, the first exposure occurred more than five years before the clinical onset of the condition under consideration. operational service made a material contribution to the veteran receiving greater than 20 ppm-years of cumulative exposure to benzene before the clinical onset of the condition under consideration, where the first exposure occurred more than five years before the clinical onset of the condition under consideration. Clinical onset and eligible service [36792]
Acute myeloid leukaemia - Exposure to AVGAS or petroleum products containing benzene Factor
Last reviewed for CCPS 08 January 2007.
Investigative Documents
Claimant Report - Exposure AVGAS or Petroleum Products Containing Benzene - Acute Myeloid Leukaemia [CR9038] Preliminary questions [11066]
11069 — the veteran has established the causal connection between exposure to AVGAS or petroleum products containing benzene and VEA service for the clinical onset of acute myeloid leukaemia.
11070 — the veteran has established the causal connection between exposure to AVGAS or petroleum products containing benzene and operational service for the clinical onset of acute myeloid leukaemia.
or
11071 — the veteran has established the causal connection between exposure to AVGAS or petroleum products containing benzene and eligible service for the clinical onset of acute myeloid leukaemia.
Clinical onset and operational service [11070]
11073 [62] the veteran experienced inhalation, ingestion or cutaneous contact with AVGAS or petroleum products containing benzene greater than 5 percent by volume on more days than not over a continuous period of at least three months. where the veteran experienced inhalation, ingestion or cutaneous contact with AVGAS or petroleum products containing benzene greater than 5 percent by volume on more days than not over a continuous period of at least three months, the first exposure occurred at least 5 years before the clinical onset of acute myeloid leukaemia. operational service made a material contribution to the veteran experiencing inhalation, ingestion or cutaneous contact with AVGAS or petroleum products containing benzene greater than 5 percent by volume on more days than not over a continuous period of at least three months where the first exposure occurred at least 5 years before the clinical onset of acute myeloid leukaemia. Clinical onset and eligible service [11071]
Acute myeloid leukaemia - Inability to obtain appropriate clinical management for acute myeloid leukaemia Factor
Last reviewed for CCPS 08 January 2007.
Investigative Documents
Medical Report - Inability to Obtain Appropriate Clinical Management - [GQACM] Preliminary questions [5338] 11109 — the condition under consideration has been accepted on the basis of inability to obtain appropriate clinical management for the condition under consideration.
7334 [70] the clinical onset of the condition under consideration occurred after the end of the veteran's last period of VEA service. the condition under consideration permanently worsened. the veteran was unable to obtain appropriate clinical management for the condition under consideration at some time.
7379 [73] the inability to obtain appropriate clinical management for the condition under consideration contributed to the clinical worsening of the condition under consideration. 11234 — the veteran has established the causal connection between the inability to obtain appropriate clinical management for the condition under consideration and VEA service for the clinical worsening of the condition under consideration. 11235 — the veteran has established the causal connection between the inability to obtain appropriate clinical management for the condition under consideration and operational service for the clinical worsening of the condition under consideration. or 11236 — the veteran has established the causal connection between the inability to obtain appropriate clinical management for the condition under consideration and eligible service for the clinical worsening of the condition under consideration. Clinical worsening and operational service [11235] or 7390 — the identified illness or injury which prevented the veteran from obtaining appropriate clinical management for the condition under consideration is causally related to operational service. [77] [78] Clinical worsening and eligible service [11236] or 7391 — the identified illness or injury which prevented the veteran from obtaining appropriate clinical management for the condition under consideration is causally related to eligible service. [77] [78]
Acute myeloid leukaemia - Myelodysplastic disorder Factor
Last reviewed for CCPS 08 January 2007.
Preliminary questions [36753]
36754 [85] there is some evidence that myelodysplastic disorder may be a factor in the development of the condition under consideration.
36755 [85] the veteran has had myelodysplastic disorder at some time.
36756 [86] the veteran had myelodysplastic disorder immediately before the clinical onset of acute myeloid leukaemia. [87]
36757 — the veteran has established the causal connection between myelodysplastic disorder and VEA service for the clinical onset of acute myeloid leukaemia.
36758 — the veteran has established the causal connection between myelodysplastic disorder and operational service for the clinical onset of acute myeloid leukaemia.
or
36759 — the veteran has established the causal connection between myelodysplastic disorder and eligible service for the clinical onset of acute myeloid leukaemia.
Clinical onset and operational service [36758]
36760 — the veteran's myelodysplastic disorder is causally related to operational service. [88] [89]
Clinical onset and eligible service [36759]
36761 — the veteran's myelodysplastic disorder is causally related to eligible service. [90] [89]
Acute myeloid leukaemia - Pipe smoking Factor
Last reviewed for CCPS 08 January 2007.
Investigative Documents
Claimant Report - Smoking [CRD905] [41] Claimant Report - Smoking [CRV905] Preliminary questions [22139]
4880 [92] the veteran has ever smoked pipe tobacco. 22137 — the veteran has established the causal connection between the pipe smoking and VEA service for the clinical onset of acute myeloid leukaemia. 22144 — the veteran has established the causal connection between the pipe smoking and operational service for the clinical onset of acute myeloid leukaemia. or 22145 — the veteran has established the causal connection between the pipe smoking and eligible service for the clinical onset of acute myeloid leukaemia. Clinical onset and operational service [22144] 4911 — the veteran has some period or periods of pipe smoking that are causally related to operational service. [94] Clinical onset and eligible service [22145]
4913 — the veteran has some period or periods of pipe smoking that are causally related to eligible service. [96]
Acute myeloid leukaemia - Smoking tobacco products - material contribution Factor
Last reviewed for CCPS 08 January 2007.
Investigative Documents
Claimant Report - Smoking [CRD905] [41] Claimant Report - Smoking [CRV905] Preliminary questions [35481] 35482 — the veteran has established the causal connection between smoking tobacco products and VEA service for the clinical onset of acute myeloid leukaemia. 35483 — the veteran has established the causal connection between smoking tobacco products and operational service for the clinical onset of acute myeloid leukaemia. or 35484 — the veteran has established the causal connection between smoking tobacco products and eligible service for the clinical onset of acute myeloid leukaemia. Clinical onset and operational service [35483] Clinical onset and eligible service [35484]
Acute myeloid leukaemia - Therapeutic radiation Factor
Last reviewed for CCPS 08 January 2007.
Preliminary questions [1403]
7617 [103] there is some evidence that therapeutic radiation may be a factor in the onset of acute myeloid leukaemia.
5031 [103] the veteran has received a course of therapeutic radiation at some time.
1411 — the veteran has established the causal connection between the course of therapeutic radiation and VEA service for the clinical onset of acute myeloid leukaemia.
5325 — the veteran has established the causal connection between the course of therapeutic radiation and eligible service for the clinical onset of acute myeloid leukaemia.
or
1412 — the veteran has established the causal connection between the course of therapeutic radiation and operational service for the clinical onset of acute myeloid leukaemia.
Clinical onset and operational service [1412]
5320 [104] the veteran underwent a course of therapeutic radiation where the first exposure occurred at least one year before the clinical onset of acute myeloid leukaemia. the course of therapeutic radiation was undertaken for an illness or injury which is identifiable.
36762 [106] the veteran underwent the course of therapeutic radiation where the first exposure occurred at least one year before the clinical onset of acute myeloid leukaemia for treatment of an illness or injury which is identifiable. 5326 — the identified illness or injury for which the course of therapeutic radiation was received is causally related to operational service. [107] [108] Clinical onset and eligible service [5325]
36764 [111] the veteran underwent the course of therapeutic radiation where the first exposure occurred at least two years before the clinical onset of acute myeloid leukaemia for treatment of an illness or injury which is identifiable. [112]
5327 — the identified illness or injury for which the course of therapeutic radiation was received is causally related to eligible service. [113] [108]
Acute myeloid leukaemia - Thorium dioxide (Thorotrast) Factor
Last reviewed for CCPS 08 January 2007.
Preliminary questions [36771]
36772 [114] there is some evidence that thorium dioxide (Thorotrast) may be a factor in the development of the condition under consideration.
36773 [114] the veteran has received thorium dioxide (Thorotrast) at some time.
36774 — the veteran has established the causal connection between thorium dioxide (Thorotrast) and VEA service for the clinical onset of acute myeloid leukaemia.
36776 — the veteran has established the causal connection between thorium dioxide (Thorotrast) and eligible service for the clinical onset of acute myeloid leukaemia.
or
36775 — the veteran has established the causal connection between thorium dioxide (Thorotrast) and operational service for the clinical onset of acute myeloid leukaemia.
Clinical onset and operational service [36775]
36777 [115] the veteran received thorium dioxide (Thorotrast) at least one year before the clinical onset of the condition under consideration. 36779 — the veteran received thorium dioxide (Thorotrast) for an illness or injury which is identifiable. 36782 — the identified illness or injury, for which the veteran received thorium dioxide (Thorotrast), is causally related to operational service. [117] [118] Clinical onset and eligible service [36776] 36779 — the veteran received thorium dioxide (Thorotrast) for an illness or injury which is identifiable.
36783 — the identified illness or injury, for which the veteran received thorium dioxide (Thorotrast), is causally related to eligible service. [122] [118]
Links
[1] http://www.rma.gov.au/assets/SOP/2024/a87c4e8224/021.pdf
[2] http://www.rma.gov.au/assets/SOP/2024/a111ec6770/022.pdf
[3] https://clik.dva.gov.au/system/files/media/SOP%20Bulletin%20241_0.pdf
[4] https://clik.dva.gov.au/user/login?destination=comment/reply/63200%23comment-form
[5] https://clik.dva.gov.au/ccpsclaimant-240
[6] https://clik.dva.gov.au/1659-atomic-radiation
[7] clikpopup://CCPS/reject31995No
[8] clikpopup://CCPS/reject36768No
[9] clikpopup://CCPS/reject36769No
[10] clikpopup://CCPS/rejectwilful
[11] clikpopup://CCPS/reject32001No
[12] clikpopup://CCPS/reject32003No
[13] clikpopup://CCPS/reject32002No
[14] https://clik.dva.gov.au/ccpsclaimant-192
[15] clikpopup://CCPS/Exposed to benzene for 300 days in 2 years before onset of AML
[16] clikpopup://CCPS/reject22562No
[17] clikpopup://CCPS/reject22564No
[18] clikpopup://CCPS/reject37027No
[19] clikpopup://CCPS/reject22566No
[20] clikpopup://CCPS/reject22569No
[21] clikpopup://CCPS/reject22640No
[22] https://clik.dva.gov.au/ccpsclaimant-78
[23] https://clik.dva.gov.au/ccpsg009rc-30
[24] https://clik.dva.gov.au/standard-commentary-120
[25] clikpopup://CCPS/reject587No
[26] clikpopup://CCPS/210reject22383
[27] clikpopup://CCPS/reject36784No
[28] clikpopup://CCPS/reject591No
[29] clikpopup://CCPS/reject9004No
[30] clikpopup://CCPS/Morbidly obese for five years in 10 years before onset of AML
[31] clikpopup://CCPS/reject9005No
[32] https://clik.dva.gov.au/ccpsb003rc
[33] clikpopup://CCPS/Had chemotherapy as factor for AML
[34] clikpopup://CCPS/Chemotherapy before clinical onset of AML
[35] clikpopup://CCPS/reject22575No
[36] clikpopup://CCPS/reject22628No
[37] clikpopup://CCPS/reject22576No
[38] clikpopup://CCPS/reject5336No
[39] clikpopup://CCPS/reject5336,5337No
[40] clikpopup://CCPS/reject5337No
[41] https://clik.dva.gov.au/ccpsclaimant-115
[42] clikpopup://CCPS/Cigar smoking
[43] clikpopup://CCPS/Ever smoked cigars
[44] clikpopup://CCPS/reject4915No
[45] clikpopup://CCPS/reject22142No
[46] https://clik.dva.gov.au/ccpsb003rc-2
[47] clikpopup://CCPS/reject22143No
[48] clikpopup://CCPS/reject4922No
[49] clikpopup://CCPS/Cigarette smoking
[50] clikpopup://CCPS/reject5803No
[51] https://clik.dva.gov.au/reasons-decision-160
[52] clikpopup://CCPS/reject22135No
[53] clikpopup://CCPS/reject3521No
[54] clikpopup://CCPS/20ppm-years of benzene exposure before onset of AML
[55] clikpopup://CCPS/reject36793No
[56] clikpopup://CCPS/reject36797No
[57] clikpopup://CCPS/reject37028No
[58] clikpopup://CCPS/reject36794No
[59] clikpopup://CCPS/reject36798No
[60] clikpopup://CCPS/reject37029No
[61] https://clik.dva.gov.au/ccpsclaimant-165
[62] https://clik.dva.gov.au/ccpsb003rc-5
[63] clikpopup://CCPS/reject11073No
[64] clikpopup://CCPS/reject22571No
[65] clikpopup://CCPS/reject11238No
[66] clikpopup://CCPS/reject11081No
[67] clikpopup://CCPS/reject22573No
[68] clikpopup://CCPS/reject11240No
[69] https://clik.dva.gov.au/ccpsother-31
[70] https://clik.dva.gov.au/node/71835
[71] clikpopup://CCPS/Reject/OnsetAfterService
[72] clikpopup://CCPS/Reject/NoPermanentWorsening
[73] clikpopup://CCPS/AML/ACM - contributed to worsening
[74] clikpopup://CCPS/ACM/NoContribution
[75] clikpopup://CCPS/ACM/NotOpService
[76] clikpopup://CCPS/ACM/NotOperDuties
[77] clikpopup://CCPS/ACM/NoIllness
[78] clikpopup://CCPS/reject7390,7391No
[79] clikpopup://CCPS/AML/ACM %C2%96 onset prior to operational service
[80] clikpopup://CCPS/ACM/OnsetFailOper
[81] clikpopup://CCPS/ACM/NotEligService
[82] clikpopup://CCPS/ACM/NotEligDuties
[83] clikpopup://CCPS/AML/ACM %C2%96 onset prior to eligible service
[84] clikpopup://CCPS/ACM/OnsetFailElig
[85] https://clik.dva.gov.au/ccpsb003rc-0
[86] clikpopup://CCPS/Myelodysplastic disorder before onset of AML
[87] clikpopup://CCPS/reject36756No
[88] clikpopup://CCPS/reject36760No
[89] clikpopup://CCPS/reject36760,36761No
[90] clikpopup://CCPS/reject36761No
[91] clikpopup://CCPS/Pipe smoking
[92] clikpopup://CCPS/Ever smoked pipe tobacco
[93] clikpopup://CCPS/reject4880No
[94] clikpopup://CCPS/reject22146No
[95] clikpopup://CCPS/reject22147No
[96] clikpopup://CCPS/reject4913No
[97] clikpopup://CCPS/Smoked cigarettes, pipe tobacco or cigars at some time
[98] clikpopup://CCPS/reject30303No
[99] clikpopup://CCPS/reject35485No
[100] clikpopup://CCPS/reject35487No
[101] clikpopup://CCPS/reject35486No
[102] clikpopup://CCPS/reject35488No
[103] https://clik.dva.gov.au/ccpsb029rc-15
[104] clikpopup://CCPS/Course of therapeutic radiation one year prior to onset of AML
[105] clikpopup://CCPS/reject5320No
[106] clikpopup://CCPS/Course of therapeutic radiation one year prior to onset of AML for identifiable illness
[107] clikpopup://CCPS/reject36762No
[108] clikpopup://CCPS/reject5326,5327No
[109] clikpopup://CCPS/TR with first exposure 2 years before onset of AML
[110] clikpopup://CCPS/reject36763No
[111] clikpopup://CCPS/TR with first exposure 2 years before onset of AML for identifiable illness
[112] clikpopup://CCPS/reject36764No
[113] clikpopup://CCPS/reject5327No
[114] https://clik.dva.gov.au/ccpsb044rc
[115] clikpopup://CCPS/Received Thorotrast 1 year before onset of AML
[116] clikpopup://CCPS/reject36777No
[117] clikpopup://CCPS/reject36780No
[118] clikpopup://CCPS/reject36782,36783No
[119] clikpopup://CCPS/Received Thorotrast 2 years before onset of AML
[120] clikpopup://CCPS/reject36778No
[121] clikpopup://CCPS/reject36781No
[122] clikpopup://CCPS/reject36783No