Tooth Loss F054
Current RMA Instruments
Reasonable Hypothesis SOP | 29 of 2025 |
---|---|
Balance of Probabilities SOP | 30 of 2025 |
Changes from previous Intruments
ICD Coding
- ICD-10-AM Codes: K08.1, K08.3, S02.5
Brief Description
Tooth loss means partial or complete permanent loss of a natural adult tooth. Adult teeth, also called permanent or secondary teeth, usually replace baby teeth between the ages of 6 and 12 years old. Wisdom teeth, which are also part of the adult set, usually come in between ages 17 and 21 years old. Sometimes, when a tooth is lost, part of the root of the tooth that sits in the jawbone may still remain. This SOP covers tooth loss with or without retained dental root.
Confirming the diagnosis
Confirmation of tooth loss requires dental or medical records that identifies the affected tooth or teeth.
The tooth or teeth affected should be specified in the diagnostic label used.
Additional diagnoses covered by SOP
- Fracture of tooth
- Tooth Loss due to surgical extraction
Conditions not covered by SOP
- Dental caries* - Tooth decay (dental caries) SOP
- Dental pulp disease* - Dental pulp and periapical disease SOP
- Periodontitis* - Periodontitis SOP
- Tooth wear* - Tooth wear SOP
- Superficial tooth wear confined to the enamel - Not a disease
*another SOP applies
#non-SOP condition
Clinical onset
Clinical onset is when the partial or complete loss of a tooth or teeth occurred. In some cases, the date of the injury or disease that led to the tooth loss may differ from the actual date of tooth loss and should not be used as the clinical onset date. Each instance of tooth loss- or loss of a group of teeth resulting from a single cause- should be regarded as a separate clinical onset.
Clinical worsening
The only worsening factor is inability to obtain appropriate clinical management. The loss of an additional tooth or group of teeth should be considered a new condition and diagnosed separately. Similarly, if a disease develops as a result of the tooth loss, it should be treated as a new condition- not as a clinical worsening of the original tooth loss.
Source URL: https://clik.dva.gov.au/ccps-medical-research-library/sops-grouped-icd-body-system/h-l/loss-teeth-f054-k081k083
Rulebase for loss of teeth
<h5>Current RMA Instruments</h5><div class="tablesaw-bar tablesaw-mode-swipe tablesaw-all-cols-visible"><div class="tablesaw-advance minimap"> </div></div><div class="tablesaw-overflow"><table class="tablesaw tablesaw-swipe" border="0" cellpadding="0" cellspacing="0" width="0" data-tablesaw-mode="swipe" data-tablesaw-minimap="" id="tablesaw-4660"><thead><tr><th><h5><a class="external-processed" href="http://www.rma.gov.au/assets/SOP/2025/45a843d313/029.pdf" target="_blank" rel="nofollow noopener"><u>Reasonable Hypothesis SOP</u></a><svg class="svg-inline--fa fa-arrow-up-right-from-square fa-sm mx-2" aria-labelledby="svg-inline--fa-title-SR6DG23iJgqA" data-prefix="fal" data-icon="arrow-up-right-from-square" role="img" xmlns="http://www.w3.org/2000/svg" viewbox="0 0 512 512" data-fa-i2svg=""><path fill="currentColor" d="M336 0c-8.8 0-16 7.2-16 16s7.2 16 16 16H457.4L212.7 276.7c-6.2 6.2-6.2 16.4 0 22.6s16.4 6.2 22.6 0L480 54.6V176c0 8.8 7.2 16 16 16s16-7.2 16-16V16c0-8.8-7.2-16-16-16H336zM64 32C28.7 32 0 60.7 0 96V448c0 35.3 28.7 64 64 64H416c35.3 0 64-28.7 64-64V304c0-8.8-7.2-16-16-16s-16 7.2-16 16V448c0 17.7-14.3 32-32 32H64c-17.7 0-32-14.3-32-32V96c0-17.7 14.3-32 32-32H208c8.8 0 16-7.2 16-16s-7.2-16-16-16H64z"></path></svg></h5></th><th><h5>29 of 2025</h5></th></tr></thead><tbody><tr><td><h5><a class="external-processed" href="http://www.rma.gov.au/assets/SOP/2025/075832e893/030.pdf" target="_blank" rel="nofollow noopener"><u>Balance of Probabilities SOP</u></a><svg class="svg-inline--fa fa-arrow-up-right-from-square fa-sm mx-2" aria-labelledby="svg-inline--fa-title-FTw3KWfPbB5b" data-prefix="fal" data-icon="arrow-up-right-from-square" role="img" xmlns="http://www.w3.org/2000/svg" viewbox="0 0 512 512" data-fa-i2svg=""><path fill="currentColor" d="M336 0c-8.8 0-16 7.2-16 16s7.2 16 16 16H457.4L212.7 276.7c-6.2 6.2-6.2 16.4 0 22.6s16.4 6.2 22.6 0L480 54.6V176c0 8.8 7.2 16 16 16s16-7.2 16-16V16c0-8.8-7.2-16-16-16H336zM64 32C28.7 32 0 60.7 0 96V448c0 35.3 28.7 64 64 64H416c35.3 0 64-28.7 64-64V304c0-8.8-7.2-16-16-16s-16 7.2-16 16V448c0 17.7-14.3 32-32 32H64c-17.7 0-32-14.3-32-32V96c0-17.7 14.3-32 32-32H208c8.8 0 16-7.2 16-16s-7.2-16-16-16H64z"></path></svg></h5></td><td><h5>30 of 2025</h5></td></tr></tbody></table></div><h5>Changes from previous Intruments</h5><drupal-media data-entity-type="media" data-entity-uuid="fd19f623-b278-40a8-8c49-73474c660209"> </drupal-media><h5> </h5><h5>ICD Coding </h5><ul><li>ICD-10-AM Codes: K08.1, K08.3, S02.5</li></ul><h5>Brief Description</h5><p>Tooth loss means partial or complete permanent loss of a natural adult tooth. Adult teeth, also called permanent or secondary teeth, usually replace baby teeth between the ages of 6 and 12 years old. Wisdom teeth, which are also part of the adult set, usually come in between ages 17 and 21 years old. Sometimes, when a tooth is lost, part of the root of the tooth that sits in the jawbone may still remain. This SOP covers tooth loss with or without retained dental root. </p><h5>Confirming the diagnosis</h5><p><span>Confirmation of tooth loss requires dental or medical records that identifies the affected tooth or teeth. </span></p><p>The tooth or teeth affected should be specified in the diagnostic label used. </p><h5>Additional diagnoses covered by SOP</h5><ul><li>Fracture of tooth</li><li>Tooth Loss due to surgical extraction </li></ul><h5>Conditions not covered by SOP</h5><ul><li>Dental caries* - Tooth decay (dental caries) SOP</li><li>Dental pulp disease* - Dental pulp and periapical disease SOP</li><li>Periodontitis* - Periodontitis SOP</li><li>Tooth wear* - Tooth wear SOP</li><li>Superficial tooth wear confined to the enamel - Not a disease </li></ul><p>*another SOP applies</p><p>#non-SOP condition </p><h5>Clinical onset</h5><p>Clinical onset is when the partial or complete loss of a tooth or teeth occurred. In some cases, the date of the injury or disease that led to the tooth loss may differ from the actual date of tooth loss and should not be used as the clinical onset date. Each instance of tooth loss- or loss of a group of teeth resulting from a single cause- should be regarded as a separate clinical onset. </p><h5>Clinical worsening</h5><p>The only worsening factor is inability to obtain appropriate clinical management. The loss of an additional tooth or group of teeth should be considered a new condition and diagnosed separately. Similarly, if a disease develops as a result of the tooth loss, it should be treated as a new condition- not as a clinical worsening of the original tooth loss. </p>
Source URL: https://clik.dva.gov.au/ccps-medical-research-library/statements-principles/h-l/loss-teeth-f054-k081k083/rulebase-loss-teeth
Avulsion and subsequent replantation of a tooth
Current RMA Instruments
Reasonable Hypothesis SOP | 29 of 2025 |
---|---|
Balance of Probabilities SOP | 30 of 2025 |
Changes from previous Intruments
ICD Coding
- ICD-10-AM Codes: K08.1, K08.3, S02.5
Brief Description
Tooth loss means partial or complete permanent loss of a natural adult tooth. Adult teeth, also called permanent or secondary teeth, usually replace baby teeth between the ages of 6 and 12 years old. Wisdom teeth, which are also part of the adult set, usually come in between ages 17 and 21 years old. Sometimes, when a tooth is lost, part of the root of the tooth that sits in the jawbone may still remain. This SOP covers tooth loss with or without retained dental root.
Confirming the diagnosis
Confirmation of tooth loss requires dental or medical records that identifies the affected tooth or teeth.
The tooth or teeth affected should be specified in the diagnostic label used.
Additional diagnoses covered by SOP
- Fracture of tooth
- Tooth Loss due to surgical extraction
Conditions not covered by SOP
- Dental caries* - Tooth decay (dental caries) SOP
- Dental pulp disease* - Dental pulp and periapical disease SOP
- Periodontitis* - Periodontitis SOP
- Tooth wear* - Tooth wear SOP
- Superficial tooth wear confined to the enamel - Not a disease
*another SOP applies
#non-SOP condition
Clinical onset
Clinical onset is when the partial or complete loss of a tooth or teeth occurred. In some cases, the date of the injury or disease that led to the tooth loss may differ from the actual date of tooth loss and should not be used as the clinical onset date. Each instance of tooth loss- or loss of a group of teeth resulting from a single cause- should be regarded as a separate clinical onset.
Clinical worsening
The only worsening factor is inability to obtain appropriate clinical management. The loss of an additional tooth or group of teeth should be considered a new condition and diagnosed separately. Similarly, if a disease develops as a result of the tooth loss, it should be treated as a new condition- not as a clinical worsening of the original tooth loss.
Source URL: https://clik.dva.gov.au/ccps-medical-research-library/statements-principles/h-l/loss-teeth-f054-k081k083/rulebase-loss-teeth/avulsion-and-subsequent-replantation-tooth
Dental caries
Current RMA Instruments
Reasonable Hypothesis SOP | 29 of 2025 |
---|---|
Balance of Probabilities SOP | 30 of 2025 |
Changes from previous Intruments
ICD Coding
- ICD-10-AM Codes: K08.1, K08.3, S02.5
Brief Description
Tooth loss means partial or complete permanent loss of a natural adult tooth. Adult teeth, also called permanent or secondary teeth, usually replace baby teeth between the ages of 6 and 12 years old. Wisdom teeth, which are also part of the adult set, usually come in between ages 17 and 21 years old. Sometimes, when a tooth is lost, part of the root of the tooth that sits in the jawbone may still remain. This SOP covers tooth loss with or without retained dental root.
Confirming the diagnosis
Confirmation of tooth loss requires dental or medical records that identifies the affected tooth or teeth.
The tooth or teeth affected should be specified in the diagnostic label used.
Additional diagnoses covered by SOP
- Fracture of tooth
- Tooth Loss due to surgical extraction
Conditions not covered by SOP
- Dental caries* - Tooth decay (dental caries) SOP
- Dental pulp disease* - Dental pulp and periapical disease SOP
- Periodontitis* - Periodontitis SOP
- Tooth wear* - Tooth wear SOP
- Superficial tooth wear confined to the enamel - Not a disease
*another SOP applies
#non-SOP condition
Clinical onset
Clinical onset is when the partial or complete loss of a tooth or teeth occurred. In some cases, the date of the injury or disease that led to the tooth loss may differ from the actual date of tooth loss and should not be used as the clinical onset date. Each instance of tooth loss- or loss of a group of teeth resulting from a single cause- should be regarded as a separate clinical onset.
Clinical worsening
The only worsening factor is inability to obtain appropriate clinical management. The loss of an additional tooth or group of teeth should be considered a new condition and diagnosed separately. Similarly, if a disease develops as a result of the tooth loss, it should be treated as a new condition- not as a clinical worsening of the original tooth loss.
Source URL: https://clik.dva.gov.au/ccps-medical-research-library/statements-principles/h-l/loss-teeth-f054-k081k083/rulebase-loss-teeth/dental-caries
Dental pulp disease
Current RMA Instruments
Reasonable Hypothesis SOP | 29 of 2025 |
---|---|
Balance of Probabilities SOP | 30 of 2025 |
Changes from previous Intruments
ICD Coding
- ICD-10-AM Codes: K08.1, K08.3, S02.5
Brief Description
Tooth loss means partial or complete permanent loss of a natural adult tooth. Adult teeth, also called permanent or secondary teeth, usually replace baby teeth between the ages of 6 and 12 years old. Wisdom teeth, which are also part of the adult set, usually come in between ages 17 and 21 years old. Sometimes, when a tooth is lost, part of the root of the tooth that sits in the jawbone may still remain. This SOP covers tooth loss with or without retained dental root.
Confirming the diagnosis
Confirmation of tooth loss requires dental or medical records that identifies the affected tooth or teeth.
The tooth or teeth affected should be specified in the diagnostic label used.
Additional diagnoses covered by SOP
- Fracture of tooth
- Tooth Loss due to surgical extraction
Conditions not covered by SOP
- Dental caries* - Tooth decay (dental caries) SOP
- Dental pulp disease* - Dental pulp and periapical disease SOP
- Periodontitis* - Periodontitis SOP
- Tooth wear* - Tooth wear SOP
- Superficial tooth wear confined to the enamel - Not a disease
*another SOP applies
#non-SOP condition
Clinical onset
Clinical onset is when the partial or complete loss of a tooth or teeth occurred. In some cases, the date of the injury or disease that led to the tooth loss may differ from the actual date of tooth loss and should not be used as the clinical onset date. Each instance of tooth loss- or loss of a group of teeth resulting from a single cause- should be regarded as a separate clinical onset.
Clinical worsening
The only worsening factor is inability to obtain appropriate clinical management. The loss of an additional tooth or group of teeth should be considered a new condition and diagnosed separately. Similarly, if a disease develops as a result of the tooth loss, it should be treated as a new condition- not as a clinical worsening of the original tooth loss.
Source URL: https://clik.dva.gov.au/ccps-medical-research-library/statements-principles/h-l/loss-teeth-f054-k081k083/rulebase-loss-teeth/dental-pulp-disease
Direct physical trauma resulting in avulsion of the tooth
Current RMA Instruments
Reasonable Hypothesis SOP | 29 of 2025 |
---|---|
Balance of Probabilities SOP | 30 of 2025 |
Changes from previous Intruments
ICD Coding
- ICD-10-AM Codes: K08.1, K08.3, S02.5
Brief Description
Tooth loss means partial or complete permanent loss of a natural adult tooth. Adult teeth, also called permanent or secondary teeth, usually replace baby teeth between the ages of 6 and 12 years old. Wisdom teeth, which are also part of the adult set, usually come in between ages 17 and 21 years old. Sometimes, when a tooth is lost, part of the root of the tooth that sits in the jawbone may still remain. This SOP covers tooth loss with or without retained dental root.
Confirming the diagnosis
Confirmation of tooth loss requires dental or medical records that identifies the affected tooth or teeth.
The tooth or teeth affected should be specified in the diagnostic label used.
Additional diagnoses covered by SOP
- Fracture of tooth
- Tooth Loss due to surgical extraction
Conditions not covered by SOP
- Dental caries* - Tooth decay (dental caries) SOP
- Dental pulp disease* - Dental pulp and periapical disease SOP
- Periodontitis* - Periodontitis SOP
- Tooth wear* - Tooth wear SOP
- Superficial tooth wear confined to the enamel - Not a disease
*another SOP applies
#non-SOP condition
Clinical onset
Clinical onset is when the partial or complete loss of a tooth or teeth occurred. In some cases, the date of the injury or disease that led to the tooth loss may differ from the actual date of tooth loss and should not be used as the clinical onset date. Each instance of tooth loss- or loss of a group of teeth resulting from a single cause- should be regarded as a separate clinical onset.
Clinical worsening
The only worsening factor is inability to obtain appropriate clinical management. The loss of an additional tooth or group of teeth should be considered a new condition and diagnosed separately. Similarly, if a disease develops as a result of the tooth loss, it should be treated as a new condition- not as a clinical worsening of the original tooth loss.
Source URL: https://clik.dva.gov.au/ccps-medical-research-library/statements-principles/h-l/loss-teeth-f054-k081k083/rulebase-loss-teeth/direct-physical-trauma-resulting-avulsion-tooth
Fracture or disruption of the alveolar bone
Current RMA Instruments
Reasonable Hypothesis SOP | 29 of 2025 |
---|---|
Balance of Probabilities SOP | 30 of 2025 |
Changes from previous Intruments
ICD Coding
- ICD-10-AM Codes: K08.1, K08.3, S02.5
Brief Description
Tooth loss means partial or complete permanent loss of a natural adult tooth. Adult teeth, also called permanent or secondary teeth, usually replace baby teeth between the ages of 6 and 12 years old. Wisdom teeth, which are also part of the adult set, usually come in between ages 17 and 21 years old. Sometimes, when a tooth is lost, part of the root of the tooth that sits in the jawbone may still remain. This SOP covers tooth loss with or without retained dental root.
Confirming the diagnosis
Confirmation of tooth loss requires dental or medical records that identifies the affected tooth or teeth.
The tooth or teeth affected should be specified in the diagnostic label used.
Additional diagnoses covered by SOP
- Fracture of tooth
- Tooth Loss due to surgical extraction
Conditions not covered by SOP
- Dental caries* - Tooth decay (dental caries) SOP
- Dental pulp disease* - Dental pulp and periapical disease SOP
- Periodontitis* - Periodontitis SOP
- Tooth wear* - Tooth wear SOP
- Superficial tooth wear confined to the enamel - Not a disease
*another SOP applies
#non-SOP condition
Clinical onset
Clinical onset is when the partial or complete loss of a tooth or teeth occurred. In some cases, the date of the injury or disease that led to the tooth loss may differ from the actual date of tooth loss and should not be used as the clinical onset date. Each instance of tooth loss- or loss of a group of teeth resulting from a single cause- should be regarded as a separate clinical onset.
Clinical worsening
The only worsening factor is inability to obtain appropriate clinical management. The loss of an additional tooth or group of teeth should be considered a new condition and diagnosed separately. Similarly, if a disease develops as a result of the tooth loss, it should be treated as a new condition- not as a clinical worsening of the original tooth loss.
Source URL: https://clik.dva.gov.au/ccps-medical-research-library/statements-principles/h-l/loss-teeth-f054-k081k083/rulebase-loss-teeth/fracture-or-disruption-alveolar-bone
Fracture or luxation of the tooth
Current RMA Instruments
Reasonable Hypothesis SOP | 29 of 2025 |
---|---|
Balance of Probabilities SOP | 30 of 2025 |
Changes from previous Intruments
ICD Coding
- ICD-10-AM Codes: K08.1, K08.3, S02.5
Brief Description
Tooth loss means partial or complete permanent loss of a natural adult tooth. Adult teeth, also called permanent or secondary teeth, usually replace baby teeth between the ages of 6 and 12 years old. Wisdom teeth, which are also part of the adult set, usually come in between ages 17 and 21 years old. Sometimes, when a tooth is lost, part of the root of the tooth that sits in the jawbone may still remain. This SOP covers tooth loss with or without retained dental root.
Confirming the diagnosis
Confirmation of tooth loss requires dental or medical records that identifies the affected tooth or teeth.
The tooth or teeth affected should be specified in the diagnostic label used.
Additional diagnoses covered by SOP
- Fracture of tooth
- Tooth Loss due to surgical extraction
Conditions not covered by SOP
- Dental caries* - Tooth decay (dental caries) SOP
- Dental pulp disease* - Dental pulp and periapical disease SOP
- Periodontitis* - Periodontitis SOP
- Tooth wear* - Tooth wear SOP
- Superficial tooth wear confined to the enamel - Not a disease
*another SOP applies
#non-SOP condition
Clinical onset
Clinical onset is when the partial or complete loss of a tooth or teeth occurred. In some cases, the date of the injury or disease that led to the tooth loss may differ from the actual date of tooth loss and should not be used as the clinical onset date. Each instance of tooth loss- or loss of a group of teeth resulting from a single cause- should be regarded as a separate clinical onset.
Clinical worsening
The only worsening factor is inability to obtain appropriate clinical management. The loss of an additional tooth or group of teeth should be considered a new condition and diagnosed separately. Similarly, if a disease develops as a result of the tooth loss, it should be treated as a new condition- not as a clinical worsening of the original tooth loss.
Source URL: https://clik.dva.gov.au/ccps-medical-research-library/statements-principles/h-l/loss-teeth-f054-k081k083/rulebase-loss-teeth/fracture-or-luxation-tooth
Inability to obtain appropriate clinical management for loss of teeth
Current RMA Instruments
Reasonable Hypothesis SOP | 29 of 2025 |
---|---|
Balance of Probabilities SOP | 30 of 2025 |
Changes from previous Intruments
ICD Coding
- ICD-10-AM Codes: K08.1, K08.3, S02.5
Brief Description
Tooth loss means partial or complete permanent loss of a natural adult tooth. Adult teeth, also called permanent or secondary teeth, usually replace baby teeth between the ages of 6 and 12 years old. Wisdom teeth, which are also part of the adult set, usually come in between ages 17 and 21 years old. Sometimes, when a tooth is lost, part of the root of the tooth that sits in the jawbone may still remain. This SOP covers tooth loss with or without retained dental root.
Confirming the diagnosis
Confirmation of tooth loss requires dental or medical records that identifies the affected tooth or teeth.
The tooth or teeth affected should be specified in the diagnostic label used.
Additional diagnoses covered by SOP
- Fracture of tooth
- Tooth Loss due to surgical extraction
Conditions not covered by SOP
- Dental caries* - Tooth decay (dental caries) SOP
- Dental pulp disease* - Dental pulp and periapical disease SOP
- Periodontitis* - Periodontitis SOP
- Tooth wear* - Tooth wear SOP
- Superficial tooth wear confined to the enamel - Not a disease
*another SOP applies
#non-SOP condition
Clinical onset
Clinical onset is when the partial or complete loss of a tooth or teeth occurred. In some cases, the date of the injury or disease that led to the tooth loss may differ from the actual date of tooth loss and should not be used as the clinical onset date. Each instance of tooth loss- or loss of a group of teeth resulting from a single cause- should be regarded as a separate clinical onset.
Clinical worsening
The only worsening factor is inability to obtain appropriate clinical management. The loss of an additional tooth or group of teeth should be considered a new condition and diagnosed separately. Similarly, if a disease develops as a result of the tooth loss, it should be treated as a new condition- not as a clinical worsening of the original tooth loss.
Source URL: https://clik.dva.gov.au/ccps-medical-research-library/statements-principles/h-l/loss-teeth-f054-k081k083/rulebase-loss-teeth/inability-obtain-appropriate-clinical-management-loss-teeth
Periodontitis
Current RMA Instruments
Reasonable Hypothesis SOP | 29 of 2025 |
---|---|
Balance of Probabilities SOP | 30 of 2025 |
Changes from previous Intruments
ICD Coding
- ICD-10-AM Codes: K08.1, K08.3, S02.5
Brief Description
Tooth loss means partial or complete permanent loss of a natural adult tooth. Adult teeth, also called permanent or secondary teeth, usually replace baby teeth between the ages of 6 and 12 years old. Wisdom teeth, which are also part of the adult set, usually come in between ages 17 and 21 years old. Sometimes, when a tooth is lost, part of the root of the tooth that sits in the jawbone may still remain. This SOP covers tooth loss with or without retained dental root.
Confirming the diagnosis
Confirmation of tooth loss requires dental or medical records that identifies the affected tooth or teeth.
The tooth or teeth affected should be specified in the diagnostic label used.
Additional diagnoses covered by SOP
- Fracture of tooth
- Tooth Loss due to surgical extraction
Conditions not covered by SOP
- Dental caries* - Tooth decay (dental caries) SOP
- Dental pulp disease* - Dental pulp and periapical disease SOP
- Periodontitis* - Periodontitis SOP
- Tooth wear* - Tooth wear SOP
- Superficial tooth wear confined to the enamel - Not a disease
*another SOP applies
#non-SOP condition
Clinical onset
Clinical onset is when the partial or complete loss of a tooth or teeth occurred. In some cases, the date of the injury or disease that led to the tooth loss may differ from the actual date of tooth loss and should not be used as the clinical onset date. Each instance of tooth loss- or loss of a group of teeth resulting from a single cause- should be regarded as a separate clinical onset.
Clinical worsening
The only worsening factor is inability to obtain appropriate clinical management. The loss of an additional tooth or group of teeth should be considered a new condition and diagnosed separately. Similarly, if a disease develops as a result of the tooth loss, it should be treated as a new condition- not as a clinical worsening of the original tooth loss.
Source URL: https://clik.dva.gov.au/ccps-medical-research-library/statements-principles/h-l/loss-teeth-f054-k081k083/rulebase-loss-teeth/periodontitis