The distinction between aggravations and sequelae has been discussed at 10.6 and 10.7, though specifically in relation to cases of physical injury as opposed to disease.

Naturally, aggravations and sequelae apply also to disease cases.

There is lit — tle difference between the investigation of aggravation or sequelae cases regardless of whether the primary condition was an injury or a disease. All aggravation cases require consideration of both the medical evidence and the circumstances. However, in s — e — quelae cases, (i.e. where the condition has either progressed or spontaneously transformed without further workplace influence), the medical evidence is the primary consideration.